What is Immunotherapy

Immunotherapy — CAR-T therapy revolutionize the cancer treatment

There is a rapidly emerging immunotherapy approach called cancer immunotherapy. This approach consists of collecting and using someone‘s own immune cells to treat their cancer. To learn more…

CAR T-cell therapy is a form of immunotherapy that uses T–cells from a patient’s own immune system to help them fight cancer. Typically, a sample of a patient’s T–cells are collected from their blood, then modified to produce special structures called chimeric antigen receptors (CARs) on their surface. When these CAR T–cells are re–infused into the patient, the new receptors enable them to latch onto and kill specific antigens on the patient’s tumor cells.

CAR T-cell therapy is a form of immunotherapy that uses T–cells from a patient’s own immune system to help them fight cancer.
Currently, CAR T-cell therapy is FDA approved as a standard of care for some forms of aggressive, refractory non-Hodgkin lymphoma and for patients with relapsed or refractory acute lymphoblastic leukemia. CAR T-cell therapy has been shown to be highly effective in fighting these cancers. Clinical trials have shown very promising results in “non-option” end-stage patients with a full recovery of up to 92% in those who possessed Acute Lymphocytic Leukemia. In addition, there are over 800 ongoing trials of CAR T-cell therapy for other forms of blood cancer and solid tumors.

CAR T-Cell therapy’s progress so far

CAR T-cell immunotherapy uses one’s own immune cells to fight cancer

Two CAR T-cell therapies received FDA approval in 2017 for treating B cell leukemia and lymphoma

Both CAR T-cell therapies have reported over 80% response rate in the intended-to-treat cancer patient group for the patients who fail chemotherapy and radiation

Thousands of cancer patients have entered remission following CAR T-cell treatment

Billions of dollars are currently funding over 800 CAR T-cell clinical trials worldwide targeting every different cancer types.

With increased focus and technology, many more breakthroughs are expected in fighting against cancer with our own cells

Every day, our body’s immune system works diligently to help us stay healthy and strong. It is a complicated network of different kinds of blood cells and hormones, all of which work in tandem to stave off infections, eliminate mutated cells and destroy potential threats to our bodies. It is the strength of our own immune systems that medical experts have been trying to tap into in cutting edge treatments of cancer. One such treatment is immunotherapy cancer treatments. 

Immunotherapy cancer treatments are proven to help the body fight and overcome certain types of cancer. They are a powerful tool for our healthcare professionals, yet many people don’t know what immunotherapy is, how they can help ensure they have access to it, or what it can be used for. Let’s walk through the essentials and how HealthBanks can help.

 

What is Immunotherapy?

Immunotherapy cancer treatments revolve around the incredible power of our own immune systems. It takes healthy blood cells related to immune response and transforms them into super-powered cells that help the body fight cancer. Broadly, this type of treatment is a biological treatment, meaning that it relies on organic materials to help in the fight against cancer over non-organic means. 

Specifically, immunotherapy cancer treatments help existing immune system cells fight cancer. In general, our immune system does fight cancer cells it finds in the body, but cancer has a few ways of resisting these attacks. Cancers avoid the immune system in three ways: 

  • The cancer cells undergo genetic changes that make them less visible to the immune system. 
  • The cancer creates proteins on their surface that turn off immune cells. 
  • In response, cancer cells will change the normal cells around the tumor, so they interfere with how the immune system responds to the cancer cells.

 

What Types of Immunotherapy Cancer Treatments Exist? 

There are five different kinds of immunotherapy cancer treatments used by healthcare providers. Here is a breakdown of each: 

  • Immune checkpoint inhibitors are a type of pharmaceutical that blocks immune checkpoints. These checkpoints are part of your immune system’s response to ensure it doesn’t go too far in its attack. By blocking these checkpoints, the body can attack more aggressively. 
  • Monoclonal antibodies are manufactured proteins designed to bind with specific targets on cancer cells. This makes the cancer cells more visible to the immune system so it will attack more aggressively. They are sometimes referred to as “therapeutic antibodies.” 
  • Treatment vaccines for immunotherapy are different from the ones that we take to prevent disease. With immunotherapy cancer vaccines, your immune system is boosted to respond better to cancer and work harder to fight it. 
  • Immune system modulators enhance the body’s immune response against cancer. Depending on the approach, the modulators will affect specific parts of the immune system, or your entire system more generally. 
  • One of the most exciting and interesting kinds of immunotherapy cancer procedures out there is CAR-T-cell transfer therapy. For this treatment, immune cells are taken from your tumor and those that are most active in your fight against cancer are isolated. These cells are then modified to be more effective, grown in large batches and then re-introduced back into your system via injection. 

 

What Kinds of Cancer Can Be Treated with Immunotherapy?

Many different kinds of cancer can be treated with immunotherapy cancer procedures. CAR-T treatments are currently approved by the FDA to treat some forms of aggressive, refractory non-Hodgkin lymphoma and for patients with relapsed or refractory acute lymphoblastic leukemia. 

That said, one of the benefits of using a banking service is that you can store your immune cells for use in treatments that are still being developed. Since immunotherapy is such a proven strategy in many kinds of cancer, we know that its role will be expanded as new technology develops. In the coming years and decades, it may end up being used for many more types of cancer other than just non-Hodgkin lymphoma and acute lymphoblastic leukemia. 

 

Is CAR-T-Cell Transfer Therapy Effective?

There have been some incredibly promising results in trials and treatments using the CART-T cell immunotherapy cancer procedure. For patients with acute lymphocytic leukemia, clinical trials have seen a full recovery of up to 92%. Other studies have reported an over 80% response rate for patients who fail chemotherapy and radiation treatments. This is on top of the over 800 trials currently happening with CAR-T immunotherapy cancer therapy right now. 

 

How Does HealthBanks Help?

HealthBanks is one of the world’s leading banks for the proper collection and storage of cells that can be used in CAR-T immunotherapy cancer procedures. We are experts in ensuring that you have the cells you need to respond quickly to threats that could be treated with this type of immunotherapy cancer treatment. 

If you would like to store your healthy immune system cells to be used later in your life for CAR-T-cell immunotherapy cancer procedures, HealthBanks can help. Equipped with the latest in both collection and storage technology and procedures, we can ensure that your healthy cells are stored responsibly and are easily accessible if they are ever required. 

We have responsibly collected and stored, not just for T-cells but for many other kinds of important cells that are being used in the latest healthcare treatments, including cord tissue for valuable stem cells, and immune system storage. Founded by professionals in the stem cell and immune system banking industry, we have developed a reliable system that helps people prepare for the future. 

If you or your family have a history of non-Hodgkin lymphoma or acute lymphoblastic leukemia, then storing your own T-cells for potential future immunotherapy cancer treatment could help you in your fight against cancer. What’s more, storing your immune system’s cells could help in the fight against other cancers and diseases that your body needs help defeating. Contact us today to learn more about how you can prepare for the future.

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Disclaimer: The use of cord blood and immune cells is determined by the treating physician and manufacturer of the final products and is influenced by many factors, including the patient's medical condition, the characteristics of the sample, and whether the immune cells should be further modified or expanded. Cord blood has established uses in transplant medicine; however, its use in regenerative medicine is still being researched. There is no guarantee that potential medical applications being studied in the laboratory or clinical trials will become available. Cord tissue use is still in early research stages, and there is no guarantee that treatments using cord tissue will be available in the future. Cord tissue is stored whole. Additional processing prior to use will be required to extract and prepare any of the multiple cell types from cryopreserved cord tissue. Immune cells has established uses in certain blood cancer treatment; however, its use in solid cancer is still being researched. There is no guarantee that treatments being studied in the laboratory, clinical trials, or other experimental treatments will be available in the future.

HealthBanks cryopreserves immune cells that have been collected from an individual for potential future cellular therapy use. HealthBanks does not provide medical advice, treatment or care. The use of cryopreserved cells for future immunotherapies is not guaranteed. Much is yet unknown about the future of immunotherapy and the immune cells that have been cryopreserved. The use of cryopreserved cells by commercial manufacturers for CAR-T therapy production is not currently approved by the FDA. There is active research ongoing, however, there is no guarantee that your cryopreserved cells will have a future therapeutic use. Only your health care professional can help you evaluate whether your cells might be used and if so, how they might be used. HealthBanks and its shareholders, directors, officers, agents, employees, affiliates, network of providers and provider facilities, will not be liable to you or any other party for claims relating to sample collection or if your cells cannot be used, or if any harm, injury, damage or loss results from the use of your cells. For more information, please refer to HealthBanks Service Agreement.