Immunotherapy — CAR-T therapy revolutionize the cancer treatment
CAR T-cell therapy is a form of immunotherapy that uses T–cells from a patient’s own immune system to help them fight cancer. Typically, a sample of a patient’s T–cells are collected from their blood, then modified to produce special structures called chimeric antigen receptors (CARs) on their surface. When these CAR T–cells are re–infused into the patient, the new receptors enable them to latch onto and kill specific antigens on the patient’s tumor cells.
CAR T-Cell therapy’s progress so far
CAR T-cell immunotherapy uses one’s own immune cells to fight cancer
Two CAR T-cell therapies received FDA approval in 2017 for treating B cell leukemia and lymphoma
Both CAR T-cell therapies have reported over 80% response rate in the intended-to-treat cancer patient group for the patients who fail chemotherapy and radiation
Thousands of cancer patients have entered remission following CAR T-cell treatment
Billions of dollars are currently funding over 800 CAR T-cell clinical trials worldwide targeting every different cancer types.
With increased focus and technology, many more breakthroughs are expected in fighting against cancer with our own cells
Every day, our body’s immune system works diligently to help us stay healthy and strong. It is a complicated network of different kinds of blood cells and hormones, all of which work in tandem to stave off infections, eliminate mutated cells and destroy potential threats to our bodies. It is the strength of our own immune systems that medical experts have been trying to tap into in cutting edge treatments of cancer. One such treatment is immunotherapy cancer treatments.
Immunotherapy cancer treatments are proven to help the body fight and overcome certain types of cancer. They are a powerful tool for our healthcare professionals, yet many people don’t know what immunotherapy is, how they can help ensure they have access to it, or what it can be used for. Let’s walk through the essentials and how HealthBanks can help.
What is Immunotherapy?
Immunotherapy cancer treatments revolve around the incredible power of our own immune systems. It takes healthy blood cells related to immune response and transforms them into super-powered cells that help the body fight cancer. Broadly, this type of treatment is a biological treatment, meaning that it relies on organic materials to help in the fight against cancer over non-organic means.
Specifically, immunotherapy cancer treatments help existing immune system cells fight cancer. In general, our immune system does fight cancer cells it finds in the body, but cancer has a few ways of resisting these attacks. Cancers avoid the immune system in three ways:
- The cancer cells undergo genetic changes that make them less visible to the immune system.
- The cancer creates proteins on their surface that turn off immune cells.
- In response, cancer cells will change the normal cells around the tumor, so they interfere with how the immune system responds to the cancer cells.
What Types of Immunotherapy Cancer Treatments Exist?
There are five different kinds of immunotherapy cancer treatments used by healthcare providers. Here is a breakdown of each:
- Immune checkpoint inhibitors are a type of pharmaceutical that blocks immune checkpoints. These checkpoints are part of your immune system’s response to ensure it doesn’t go too far in its attack. By blocking these checkpoints, the body can attack more aggressively.
- Monoclonal antibodies are manufactured proteins designed to bind with specific targets on cancer cells. This makes the cancer cells more visible to the immune system so it will attack more aggressively. They are sometimes referred to as “therapeutic antibodies.”
- Treatment vaccines for immunotherapy are different from the ones that we take to prevent disease. With immunotherapy cancer vaccines, your immune system is boosted to respond better to cancer and work harder to fight it.
- Immune system modulators enhance the body’s immune response against cancer. Depending on the approach, the modulators will affect specific parts of the immune system, or your entire system more generally.
- One of the most exciting and interesting kinds of immunotherapy cancer procedures out there is CAR-T-cell transfer therapy. For this treatment, immune cells are taken from your tumor and those that are most active in your fight against cancer are isolated. These cells are then modified to be more effective, grown in large batches and then re-introduced back into your system via injection.
What Kinds of Cancer Can Be Treated with Immunotherapy?
Many different kinds of cancer can be treated with immunotherapy cancer procedures. CAR-T treatments are currently approved by the FDA to treat some forms of aggressive, refractory non-Hodgkin lymphoma and for patients with relapsed or refractory acute lymphoblastic leukemia.
That said, one of the benefits of using a banking service is that you can store your immune cells for use in treatments that are still being developed. Since immunotherapy is such a proven strategy in many kinds of cancer, we know that its role will be expanded as new technology develops. In the coming years and decades, it may end up being used for many more types of cancer other than just non-Hodgkin lymphoma and acute lymphoblastic leukemia.
Is CAR-T-Cell Transfer Therapy Effective?
There have been some incredibly promising results in trials and treatments using the CART-T cell immunotherapy cancer procedure. For patients with acute lymphocytic leukemia, clinical trials have seen a full recovery of up to 92%. Other studies have reported an over 80% response rate for patients who fail chemotherapy and radiation treatments. This is on top of the over 800 trials currently happening with CAR-T immunotherapy cancer therapy right now.
How Does HealthBanks Help?
HealthBanks is one of the world’s leading banks for the proper collection and storage of cells that can be used in CAR-T immunotherapy cancer procedures. We are experts in ensuring that you have the cells you need to respond quickly to threats that could be treated with this type of immunotherapy cancer treatment.
If you would like to store your healthy immune system cells to be used later in your life for CAR-T-cell immunotherapy cancer procedures, HealthBanks can help. Equipped with the latest in both collection and storage technology and procedures, we can ensure that your healthy cells are stored responsibly and are easily accessible if they are ever required.
We have responsibly collected and stored, not just for T-cells but for many other kinds of important cells that are being used in the latest healthcare treatments, including cord tissue for valuable stem cells, and immune system storage. Founded by professionals in the stem cell and immune system banking industry, we have developed a reliable system that helps people prepare for the future.
If you or your family have a history of non-Hodgkin lymphoma or acute lymphoblastic leukemia, then storing your own T-cells for potential future immunotherapy cancer treatment could help you in your fight against cancer. What’s more, storing your immune system’s cells could help in the fight against other cancers and diseases that your body needs help defeating. Contact us today to learn more about how you can prepare for the future.